† Source: Managed Markets Insight & Technology, LLC,
database as of January 2026. Certain plans may require prior
authorization.
‡ April 2025 online Pancreaze patient survey of 67
respondents. Respondents were not remunerated for their
participation in the survey.
*Patient Co-Pay Eligibility, Terms, and Conditions
Eligible patients may pay a minimum of $0 and receive up to $2,000
off the patient's co-pay or out-of-pocket expenses per
prescription fill of PANCREAZE (pancrelipase) capsules with a
maximum yearly benefit of $3,500. Out-of-pocket expenses may vary.
Patient Instructions: In order to redeem the
offer, you must have a valid prescription for PANCREAZE. This
offer may not be redeemed for cash. By using this offer, you are
certifying that you meet the eligibility criteria and will comply
with the terms and conditions below.
Terms and conditions: Offer is not transferable.
Patients are not eligible if they are covered in whole or in part
by any state program or federal healthcare program, including, but
not limited to, Medicare or Medicaid (including Medicaid managed
care), Medigap, VA, DOD, or TRICARE. Only valid in the United
States, Puerto Rico, Guam and the U.S. Virgin Islands. Offer void
where prohibited by law, taxed, or restricted. Other restrictions
may apply. This program is not health insurance. VIVUS LLC has the
right to rescind, revoke, or amend this program at any time
without notice. Your participation in this program confirms that
this offer is consistent with your insurance coverage and that you
will report the value received if required by your insurance
provider. When you use this card, you are certifying that you
understand and will comply with the program rules, terms, and
conditions.
What is PANCREAZE?
PANCREAZE is a prescription medicine used to treat people who
cannot digest food normally because their pancreas does not make
enough enzymes.
Important Safety Information
What is the most important information I should know about
PANCREAZE?
PANCREAZE may increase your chance of having a serious, rare bowel
disorder called fibrosing colonopathy that may require surgery.
Fibrosing colonopathy has been reported with high dosages of
pancreatic enzyme products, usually with use over a prolonged
period of time and in pediatric patients with cystic fibrosis.
Colonic stricture has been reported in pediatric patients less
than 12 years of age.
Take PANCREAZE exactly as prescribed by your doctor. Do not take
more or less PANCREAZE than directed by your doctor.
Call your doctor right away if you have any unusual or severe
stomach area (abdominal) pain, bloating, trouble passing stool
(having bowel movements), nausea, vomiting, or diarrhea.
What should I tell my doctor before taking PANCREAZE?
Tell your doctor if you:
- are allergic to pork (pig) products
-
have a history of blockage of your intestines, or scarring or
thickening of your bowel wall (fibrosing colonopathy)
-
have gout, kidney disease, or high blood uric acid
(hyperuricemia)
- have trouble swallowing capsules
- have any other medical condition
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
Tell your doctor about all the medicines you take, including
prescription and nonprescription medicines, vitamins, and herbal
supplements.
What are the possible side effects of PANCREAZE?
PANCREAZE may cause serious side effects, including:
-
Increase in blood uric acid levels. This may cause worsening of
swollen, painful joints (gout) caused by an increase in your
blood uric acid levels. This may occur if you have gout or renal
impairment. Contact your healthcare provider if you experience
pain, stiffness, redness or swelling of your joints.
-
Irritation of the inside of your mouth. This can happen if
PANCREAZE is not swallowed completely
-
Allergic reactions including trouble with breathing, skin
rashes, or swollen lips
-
PANCREAZE and other pancreatic enzyme products are made from the
pancreas of pigs, the same pigs people eat as pork. These pigs
may carry viruses. Although it has never been reported, it may
be possible for a person to get a viral infection from taking
pancreatic enzyme products that come from pigs.
- A rare bowel disorder called fibrosing colonopathy
The most common side effects include pain in your stomach
(abdominal pain) and gas.
These are not all the side effects of PANCREAZE. Talk to your
doctor about any side effect that bothers you or does not go away.
You may report side effects to the FDA at 1-800-FDA-1088 or
www.fda.gov/medwatch. You may also report side effects to VIVUS
LLC at 1-888-998-4887.
How do I take PANCREAZE?
- Take PANCREAZE with meals or snacks.
- Swallow capsules whole.
-
For adult and pediatric patients unable to swallow intact
capsules, the capsule contents may be sprinkled on a small
amount of acidic food with a pH of 4.5 or less (e.g.,
applesauce).
-
For pediatric patients birth to 12 months of age, PANCREAZE
capsules can also be opened, and the capsule contents sprinkled
directly into the infant's mouth.
-
Consume sufficient liquids (juice, water, breast milk, or
formula) and visually inspect an infant's mouth to ensure
complete swallowing of PANCREAZE capsules or capsule contents.
-
Do not crush or chew PANCREAZE capsules or capsule contents.
Please read the
PANCREAZE Medication Guide
and
PANCREAZE Product Information
and discuss any questions you have with your doctor.
References: 1. PANCREAZE Full Prescribing
Information. Campbell, CA: VIVUS LLC; 2024.
2. Cleveland Clinic.(n.d.). Exocrine Pancreatic
Insufficiency (EPI). Retrieved from
https://my.clevelandclinic.org/health/diseases/21577-exocrine-pancreatic-insufficiency-epi
3.
Cystic Fibrosis Foundation. (n.d.). Phthalates. Retrieved March 3,
2022, from https://www.cff.org/phthalates
